Treatment Resistant Depression and Drug Efficacy

The FDA’s alarming new push to downgrade electroshock machines to class II for people ages 18+ “who are treatment resistant or require rapid response,” makes it crucial to know what “treatment resistant,” means.

 “Treatment-resistant depression (TRD) or treatment-refractory depression is a term used in clinical psychiatry to describe cases of major depressive disorder (MDD) that do not respond adequately to appropriate courses of at least two antidepressants.


Other sources may include psychotherapy unresponsiveness under the TRD banner.

The TRD label is instrumental in justifying electroshock- it’s why I had shock at age 17. This label is deeply problematic for sooooo many reasons, so for now I’m just going to focus on one aspect; drug efficacy.

The treatment resistant label implies that drugs like antidepressants, SSRI’s, etc., are proven effective medical treatments. This isn’t so.

In the book The Emperor’s New Drugs, Doctor Irving Kirsch analyzed drug studies data, breaks down the components and explains all the complex details involved in drug studies.

Kirsch more or less shows drugs perform no better than placebo. He also digs into the erroneous chemical imbalance theory and the downsides and risks to drugs.

His placebo explanations are also helpful in understanding its role in electroshock and how people may benefit from unrelated aspects of the “procedure.” How many aspects are never factored into shock studies like the effect of telling patients being told they’re given a life saving treatment, receiving anesthesia, or their problems given concerned recognition and attention.

As you’re taking in the FDA’s reclassification document and trying to understand the surrounding issues, consider the drug efficacy/ TRD angle. This pillar of the TRD label is flawed and unscientific.

In my own experience, drugs and their impact on my health were a contributing cause of my treatment resistant depression. My “miraculous” recovery from electroshock, was in part a change up in my pill cocktail that provided a temporary reprieve from the toxic pills I became dependent on at age 13 that had been wreaking havoc on body for years.

This respite was short lived because two years later, the new drugs would cause gastroparesis, bladder paralysis, and kidney problems (among other horrible side-effects). The gastroparesis alone caused endless crippling, excruciating, isolating pain which required narcotics, which I was on for 2 years. The combination of narcs and relentless pain for two years understandably led to severe, unresponsive depression.

 My treatment resistant depression was partially caused and worsened by “medicine,” not some mysterious biological/mental condition and I haven’t even gotten to the suffering caused by shock induced permanent brain damage and disability…

Anyways, back to the book…

If you struggle with reading technical books, the Emperor’s New Drugs is available on Audible. If you don’t have an account, you can get this book for free by signing up. Also, it may be available via your local library’s media apps.

Read up.
Be informed so we can squash this latest bit if FDA insanity.
My writing in the next two months is going to be quick and dirty due to the FDA time constraints and subsequent need to provide as much crucial info as possible before the 90 day deadline, however I will do my best to not offend your grammatical senses 🙂

Balt, S. (n.d.). The Placebo Effect: It Just Gets Better and Better | Thought Broadcast. Retrieved December 29, 2015, from

Federal Register | Neurological Devices; Reclassification of Electroconvulsive Therapy Devices Intended for Use in Treating Severe Major Depressive Episode in Patients 18 Years of Age and Older Who Are Treatment Resistant or Require a Rapid Response; Effective Date of Requirement for Premarket Approval for Electroconvulsive Therapy for Certain Specified Intended Uses. (2015, December 29). Retrieved December 29, 2015, from

Hickey, P. (2013, November 21). Mad in America. Retrieved December 29, 2015, from

Kirsch, I. (2010). The emperor’s new drugs: Exploding the antidepressant myth. New York, NY: Basic Books.

Ross, C. A. (2006). Retrieved December 29, 2015, from

Wikipedia. (n.d.). Treatment-resistant depression – Wikipedia, the free encyclopedia. Retrieved December 29, 2015, from


4 thoughts on “Treatment Resistant Depression and Drug Efficacy

  1. OMFG! I am so sorry to hear about your protracted chemical rape. i worked in the mh system as a peer advocate for 30 and i saw all kinds of horror and ugly death from what the chemicals were doing to people’s bodies. I never get used to these stories. Medicine is a purely sadistic enterprise.Beings in other dimensions are astounded at what we have done to the most sensitive and vulnerable members of our species. Drugged/poisoned into submission. FEH!

    Liked by 1 person

    • Thank you! It’s truly astounding how these drugs that have been proven ineffective and dangerous with little or no long term research on health consequences is considered a front line treatment and when it doesn’t work (because they’re ineffective) procedures like electroshock are justified. It’s unthinkable.

      Liked by 1 person

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